Director Protein Production and Quality Attributes
Company: Disability Solutions
Location: San Diego
Posted on: October 19, 2024
Job Description:
Working with UsChallenging. Meaningful. Life-changing. Those
aren't words that are usually associated with a job. But working at
Bristol Myers Squibb is anything but usual. Here, uniquely
interesting work happens every day, in every department. From
optimizing a production line to the latest breakthroughs in cell
therapy, this is work that transforms the lives of patients, and
the careers of those who do it. You'll get the chance to grow and
thrive through opportunities uncommon in scale and scope, alongside
high-achieving teams rich in diversity. Take your career farther
than you thought possible.Bristol Myers Squibb recognizes the
importance of balance and flexibility in our work environment. We
offer a wide variety of competitive benefits, services and programs
that provide our employees with the resources to pursue their
goals, both at work and in their personal lives. Read more:
.Director Protein Production and Quality Attributes (San Diego,
California, USA)When you join BMS, you are joining a diverse,
high-achieving team united by a common mission. The Discovery
Biotherapeutics team at BMS seeks to understand the structure and
function of complex molecules such as bispecific antibodies,
antibody drug conjugates and endogenous proteins in order to
optimize their utility as therapeutic agents. We collaborate with
biology and translational scientists imbedded in the Thematic
Research Centers in order to prosecute Targets and Biological
pathways with disease modifying potential. By using a blend of
internal and external technologies and capabilities, we work to
discover and deliver first-in-class as well as best-in-class
molecules that warrant clinical evaluation for patient
benefit.Here, you'll get the chance to grow and thrive through
opportunities that are uncommon in scale and scope. You'll pursue
innovative ideas while advancing professionally alongside some of
the brightest minds in biopharma.As part of the Discovery
Biotherapeutics team at BMS, the Director of Protein Production and
Quality Attributes will play a key role in supporting the delivery
of a first-in-class and best-in-class biotherapeutics pipeline. The
incumbent will be responsible for leading a team of about 25
scientists across two BMS sites located in San Diego (CA) and
Cambridge (MA). The primary responsibilities include managing a
cross-site and cross-functional team focused on the production and
characterization of monoclonal antibodies, multi-specifics,
antibody-drug conjugates (ADCs), and other protein therapeutics
using state-of-the-art technology and an industry-competitive
DNA-to-protein production process. The Director role will be
crucial in innovating and advancing Discovery Biotherapeutics
function capabilities, supporting drug development initiatives, and
ensuring the success of BMS's research activities.You will work in
close collaboration with scientific leaders across the global
Research organization and beyond (e.g., Biologics Drug Product/CMC
teams) to deliver on our biologics pipeline. You must have a
thorough understanding of biologics modalities production
end-to-end (i.e., from cloning to purification and quality
analyses) in high-throughput, mid, and large-scale settings, with
documented experience of the requirements and processes needed to
advance biologics programs (including novel formats) through
discovery and into development. A proven track record of
establishing and/or using cutting-edge protein cloning, production,
and purification technologies to progress an innovative biologics
pipeline is key. Responsibilities:
- Manage, mentor, and develop a high-performing team (consisting
of PhD and non-PhD scientists) dedicated to excellence in biologics
cloning, production, purification with a focus on strategic goal
setting and talent management.
- Apply deep scientific knowledge of protein production,
concepts, and methodologies to deliver on biotherapeutics pipeline
in alignment with Discovery Biotherapeutics, including being point
person for interactions with CMC colleagues.
- Manage high-throughput, medium, and large-scale production of
biologics end-to-end (i.e., from cloning to production,
purification, and formulation).
- Advance cloning and purification platforms to produce and
characterize monoclonal and bispecific antibodies, fusion proteins,
and ADCs.
- Apply protein structural and biophysical principles to optimize
the production and manufacturability of therapeutic
candidates.
- Identify and implement new technologies, applications, and
external collaborations to support research goals including
participating in licensing and technology evaluation of platforms
as relate to the job function.
- Interface with technology providers to keep on par with
industry leading protein cloning, production, purification, and
manufacturability.
- Foster a continuous improvement mentality to drive platform
development in terms of speed, quality, and robustness, ensuring
global biologics remain aligned with industrial standards.
- Integrate analytical characterization data to optimize
biologics production.
- Ensure clear communication among team members and across teams
to foster a culture of proactive collaboration and engagement.
Basic Qualifications: Bachelor's Degree with 15+ years of academic
/ industry experienceorMaster's Degree with 12+ years of academic /
industry experienceorPhD with 8+ years of academic / industry
experience with 6+ years leadership experience.P referred
Qualifications:
- A Ph.D. in Biochemistry, Biotechnology, Molecular Biology, or a
related field
- 10+ years of increasing responsibilities and experience in
protein cloning, production, purification, and quality analyses,
preferably in an industry setting.
- Demonstrated leadership and people management skills, with the
ability to effectively lead and manage teams.
- Strong strategic vision and experience in developing and
executing strategic plans that align with organizational
goals.
- Excellent analytical and problem-solving skills, with the
ability to identify challenges and propose innovative
solutions.
- Exceptional communication and collaboration skills, with the
ability to effectively interact with cross-functional teams and
stakeholders at all levels.
- Hands-on experience with CHO and other mammalian cells for mAb
or recombinant protein production is a must.
- Experience in tech transfer, including drafting reports,
protocols, and knowledge for process transfer.
- Demonstrated ability to successfully and efficiently coordinate
multiple work streams and projects simultaneous.
- Track record of scientific publications and presentations at
meetings, or authorship of patents and regulatory documents.The
starting compensation for this job is a range from $194,000 -
$268,400 plus incentive cash and stock opportunities (based on
eligibility). The starting pay rate takes into account
characteristics of the job, such as required skills and where the
job is performed. Final, individual compensation will be decided
based on demonstrated experience.Eligibility for specific benefits
listed on our careers site may vary based on the job and location.
For more on benefits, please visit our BMS Career Site.Benefit
offerings are subject to the terms and conditions of the applicable
plans then in effect and may include the following: Medical,
pharmacy, dental and vision care. Wellbeing support such as the BMS
Living Life Better program and employee assistance programs (EAP).
Financial well-being resources and a 401(K). Financial protection
benefits such as short- and long-term disability, life insurance,
supplemental health insurance, business travel protection and
survivor support. Work-life programs include paid national holidays
and optional holidays, Global Shutdown days between Christmas and
New Year's holiday, up to 120 hours of paid vacation, up to two (2)
paid days to volunteer, sick time off, and summer hours
flexibility. Parental, caregiver, bereavement, and military leave.
Family care services such as adoption and surrogacy reimbursement,
fertility/infertility benefits, support for traveling mothers, and
child, elder and pet care resources. Other perks like tuition
reimbursement and a recognition program.If you come across a role
that intrigues you but doesn't perfectly line up with your resume,
we encourage you to apply anyway. You could be one step away from
work that will transform your life and career. Uniquely Interesting
Work, Life-changing CareersWith a single vision as inspiring as
Transforming patients' lives through science--- , every BMS
employee plays an integral role in work that goes far beyond
ordinary. Each of us is empowered to apply our individual talents
and unique perspectives in an inclusive culture, promoting
diversity in clinical trials, while our shared values of passion,
innovation, urgency, accountability, inclusion and integrity bring
out the highest potential of each of our colleagues.On-site
Protocol BMS has a diverse occupancy structure that determines
where an employee is required to conduct their work. This structure
includes site-essential, site-by-design, field-based and
remote-by-design jobs. The occupancy type that you are assigned is
determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned
facility. Site-by-design roles may be eligible for a hybrid work
model with at least 50% onsite at your assigned facility. For these
roles, onsite presence is considered an essential job function and
is critical to collaboration, innovation, productivity, and a
positive Company culture. For field-based and remote-by-design
roles the ability to physically travel to visit customers, patients
or business partners and to attend meetings on behalf of BMS as
directed is an essential job function. BMS is dedicated to ensuring
that people with disabilities can excel through a transparent
recruitment process, reasonable workplace
accommodations/adjustments and ongoing support in their roles.
Applicants can request a reasonable workplace
accommodation/adjustment prior to accepting a job offer. If you
require reasonable accommodations/adjustments in completing this
application, or in any part of the recruitment process, direct your
inquiries to . Visit to access our complete Equal Employment
Opportunity statement. BMS cares about your well-being and the
well-being of our staff, customers, patients, and communities. As a
result, the Company strongly recommends that all employees be fully
vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest
and conviction records, pursuant to applicable laws in your area.If
you live in or expect to work from Los Angeles County if hired for
this position, please visit this page for important additional
information: Any data processed in connection with role
applications will be treated in accordance with applicable data
privacy policies and regulations.
Keywords: Disability Solutions, Bellflower , Director Protein Production and Quality Attributes, Executive , San Diego, California
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